Intracranial germ cell tumors are a heterogeneous group with variable imaging appearances, biology, response to treatment and prognosis. The WHO classification of CNS tumors divides intracranial germ cell tumors into: germinoma (account for 60-80% of all cases) 2. embryonal carcinoma. yolk sac tumor Germ cell tumors of the ovary. Dr Bahman Rasuli and Radswiki et al. Germ cell tumors of the ovary account for approximately 15-20% of all ovarian tumors. In children and adolescents, up to 60% of ovarian tumors can be of germ cell origin. They include: ovarian teratoma (s): commonest primary benign tumor of ovary and commonest germ cell tumor Non-seminomatous germ cell tumors (NSGCTs) are one of the main groups of germ cell tumors (the other being seminoma ). Although they are made up of distinct histological entities, in general, they have similar radiographic appearances. They can, however, be found widely in the body, with variable imaging features, pathology, treatment and prognosis Germ cell tumors are one of the causes of anterior mediastinal mass, and any of the germ cell histologies may be identified. They can therefore be divided histologically into: seminoma; non-seminomatous germ cell tumors (NSGCT) embryonal cell carcinoma; choriocarcinoma; yolk sac tumor; teratoma: most common; mixed germ cell tumor Abstract. Germ cell tumors (GCTs) occur most frequently in the gonads and are relatively rare in other sites, such as the pineal gland, neurohypophysis, mediastinum, and retroperitoneum. GCTs are thought to originate from primordial germ cells, which migrate to the primitive gonadal glands in the urogenital ridge
PURPOSE: To evaluate the feasibility of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) in patients with germ cell tumor (GCT) to monitor treatment and differentiate residual masses after chemotherapy. MATERIALS AND METHODS: Twenty-six FDG PET studies were performed in 21 patients with GCT Germ cell tumors represent neoplasms derived from germ cells. These cells are normally found in the ovaries or testes, in which their function is to produce eggs or sperm, respectively. These gonadal sites are the most common locations for the manifestation of germ cell tumors Clinical features, radiologic findings, and treatment of pediatric germ cell tumors involving the basal ganglia and thalamus: a retrospective series of 15 cases at a single center Pediatric GCTs in the basal ganglia and thalamus are not as rare as previously considered There are no definite radiologic features distinguishing primary retroperitoneal germ cell tumors from lymphoma, retroperitoneal metastases, and retroperitoneal soft-tissue sarcoma. Brain (Fig. 10A , 10B , 10C ), liver (Fig. 10A , 10B , 10C ), lungs (Fig. 10A , 10B , 10C ), and bones (Fig. 11A , 11B , 11C , 11D ) are the common sites of metastases
Dermoid. Mediastinum is a rare site for occurrence of teratomas, most being ovarian in origin. Arise from primitive germ cell rests. Supposed to migrate along urogenital ridge to primitive gonad. Journey is interrupted in the mediastinum. May be solid or cystic. Most are cystic. Three major categories. Mature teratomas Germ cell tumors occur most frequently in the gonad but can rarely occur in extragonadal locations, usually in or near the midline. The most common extragonadal site of primary germ cell tumors is... From the archives of the AFIP. Mediastinal germ cell tumors: radiologic and pathologic correlation. | RadioGraphic Mediastinal germ cell tumors (GCTs) are a heterogeneous group of benign and malignant neoplasms with histology identical to some neoplasms of the testicle and ovary. They are thought to derive from an interruption of the migration of primitive germ cells from the urogenital ridge to the gonads during early embryogenesis.135-13 Serum tumor markers (STMs) play a critical role in the diagnosis, staging and follow-up of both seminomatous and nonseminomatous testicular germ cell neoplasms. Levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactate dehydrogenase (LDH), especially those measured after orchiectomy, also have implications for patient prognosis
Prognosis worse than gonadal germ cell tumors; 5 year disease free survival is 50 - 65% for seminomas, 20% for other subtypes. Good prognostic factors for nonseminomatous tumors: rapid decline in serum AFP or hCG after surgery and chemotherapy, no vascular invasion, no yolk sac or choriocarcinoma components Germ cell tumors of the mediastinum are histologically identical to those found in the testes and ovaries. Early diagnosis and treatment improve the survival rate. Imaging studies of teratoma demonstrate a rounded, often lobulated heterogeneous mass containing soft tissue elements with fluid and fat attenuation. Calcification is present in 20-43% of cases Testicular germ cell tumor presenting with spontaneous complete or partial regression (J Ultrasound Med 2003;22:515, J Urol 2009;182:2303, Case Rep Oncol 2017;10:846) Presents as metastasis, residual testicular germ cell tumor or both (BJU Int 2004;94:74, Case Rep Oncol 2017;10:846, Am J Surg Pathol 2006;30:858) Histologic features of testicular tumor regression include fibrous scar and germ.
INTRODUCTION. Ovarian germ cell tumors (OGCTs) are derived from primordial germ cells of the ovary ().They may be benign or malignant. These neoplasms comprise approximately 20 to 25 percent of ovarian neoplasms overall, but account for only an approximate 5 percent of all malignant ovarian neoplasms .OGCTs arise primarily in young women between 10 and 30 years of age and represent 70. germ cell tumors is sparse. In this article, we discuss the different types of extragonadal germ cell tumors in adults, their typical loca-tions, radiologic and FDG PET/CT features, and patterns of metastatic spread. Classification of Extragonadal Germ Cell Tumors Histologically, extragonadal germ cell tu-mors comprise seminomas (30-40%) an Radiology. 1990 May;175(2):499-502. Nonseminomatous germ cell tumors: enlarging masses despite chemotherapy. Panicek DM(1), Toner GC, Heelan RT, Bosl GJ. Author information: (1)Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center New York, NY 10021. In men who otherwise seem to have responded to chemotherapy for nonseminomatous. Author information: (1)Department of Radiology, National Naval Medical Center, Bethesda, Md. Malignant germ cell tumors are the most common malignant ovarian neoplasms in girls and young women. The most well known of these neoplasms are dysgerminoma, immature teratoma, endodermal sinus tumor, and a mixture of two or more of these elements 1. Neuroradiology. 2018 Jan;60(1):27-34. doi: 10.1007/s00234-017-1928-6. Epub 2017 Sep 23. Loco-regional extensions of central nervous system germ cell tumors: a retrospective radiological analysis of 100 patients
Eyas M. Hattab MD, MBA, in Practical Surgical Neuropathology: A Diagnostic Approach (Second Edition), 2018 Definition and Synonyms. Germ cell tumors (GCTs) are a heterogeneous group that are widely considered to be morphologic and immunophenotypic homologues of germinal neoplasms arising in the gonads and extragonadal sites. 1 The World Health Organization (WHO) classification of GCTs of the. Mediastinal Germ CellTumorsMediastinal Germ CellTumors Primary extragonadal germ cell tumors comprisePrimary extragonadal germ cell tumors comprise 2% to 5% of all germ cell tumors2% to 5% of all germ cell tumors Approximately two thirds of these tumors occur inApproximately two thirds of these tumors occur in the mediastinumthe mediastinum The.
Germ Cell Tumor. The book aims to provide an overview of current knowledge regarding germ cell tumors. It deals with the clinical presentations, treatment modalities, the biology and genetics of germ cell tumors in children and adults. Most chapters are focused on testicular germ cell tumors whose incidence has been increasing in young males Germ cell tumors account for 15% of anterior mediastinum tumors. Fistulas are abnormal communications between two surfaces covered by the epithelium. A fistula can occur between the bronchial tree and the adjacent anatomical structures secondary to variable etiologies. The main clinical manifestations of bronchial fistulas include hemoptysis, purulent cough, and pneumonia, which might threaten. Germ Cell Tumors It is extremely uncommon for extragonadal germ cell tumors to involve the head and neck and even more uncommon for them to actually arise from the upper aerodigestive tract. Tumors reported to involve this area include teratomas (and dermoids), yolk sac tumors (endodermal sinus tumors), choriocarcinomas, and teratocarcinosarcomas
. Radiology.987 Sep;164(3):671-4. Stage I nonseminomatous germ cell tumors of the testis: radiologic follow-up after orchidectomy. Williams MP, Husband JE, Heron CW. One hundred and forty-seven patients with clinical stage I nonseminomatous germ cell tumors of the testis were entered into a follow-up program after orchidectomy Germ cell tumors (GCTs) account for 95 percent of testicular cancers; they are divided evenly between seminomas and nonseminomatous GCTs. Testicular GCTs are rare prior to puberty [ 1 ]. Other testicular malignancies include sex cord-stromal tumors, including Leydig cell and Sertoli cell tumors, gonadoblastoma, and tumors of other cell types.
Germ cell tumors (GCTs) are classified as extragonadal if there is no evidence of a primary tumor in the testes or ovaries [ 1 ]. Extragonadal GCTs typically arise in midline locations, and specific sites vary with age. In adults, the most common sites, in order of frequency, are the anterior mediastinum, the retroperitoneum, and the pineal and. . Currently no consensus exists on the risk of malignancy in this syndrome. Several case reports show an incidence of extragonadal germ cells tumors (eGCT) of 1.5 per 1000 KS patients (OR 50 against healthy population). Malignant germ cell tumors are rare in children Visual survey of surgical pathology with 11122 high-quality images of benign and malignant neoplasms & related entities. Germ Cell Tumors - I Focused Germ Cell Tumors - I with stained slides of pathology
. Posted by Rathachai Kaewlai, M.D. Figure 1 and 2: Gray-scale longitudinal (1) and Doppler flow transverse ultrasound images (2) of the testicle show an ill-defined hypoechoic, solid mass within the testicle (intratesticular mass). There are scattered microcalcifications throughout the testicle Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with ad- serum tumor marker levels, radiology, and pathology at surgical resection of residual disease
mediastinal germ cell tumors . Fistulas are abnormal communications between two surfaces covered by the epithelium. The ﬁstula creation would be related to the rapid growth of these tumors with a mismatch between demand and blood supply. This mecha-nism leads to tumor necrosis allowing communication with adjacent structures WebPathology is a free educational resource with 11104 high quality pathology images of benign and malignant neoplasms and related entities Germ cell tumors (GCTs) that arise outside the testes or the ovaries are classified as extragonadal. Extragonadal GCTs typically arise in midline locations, and specific sites vary with age. In adults, the most common sites are the anterior mediastinum, retroperitoneum, and the pineal and suprasellar regions.. Germ cell tumors are malignant (cancerous) or nonmalignant (benign, noncancerous) tumors that are comprised mostly of germ cells. Germ cells are the cells that develop in the embryo (fetus, or unborn baby) and become the cells that make up the reproductive system in males and females. These germ cells follow a midline path through the body.
Germ cell tumors (GCTs) are classified as extragonadal if there is no evidence of a primary tumor in either the testes or the ovaries. Extragonadal GCTs typically arise in midline locations, and specific sites vary with age. In adults, the most common sites are the anterior mediastinum, retroperitoneum, and the pineal and suprasellar regions.. Germ cell tumors make up about 20% of mediastinal tumors and cysts.They are thought to arise from extragonadal germ cells.They are always associated with the thymus gland and may even be fully contained within it when small. Mediastinal germ cell tumors are not related to thymomas.The possibility of metastases from testicular or ovarian primary tumor must be excluded before a diagnosis of.
Ovarian germ cell tumor is a disease in which malignant cells form in the germ (egg) cells of the ovary.Signs of ovarian germ cell tumor are swelling of the abdomen or vaginal bleeding after menopause.; Tests that examine the ovaries, pelvic area, blood, and ovarian tissue are used to detect (find) and diagnose ovarian germ cell tumor Key words: ovarian germ cell tumor, ovarian dysgermin- omas, endodermal sinus tumor, cisplatin-based chemo- therapy. The evolution of treatment for malignant ovarian germ cell tumors has been one of the true success stories in the annals of oncology. Most of the important develop- ments have occurred during the past two decades, al
Ovarian germ cell tumor is a disease in which malignant (cancer) cells form in the germ (egg) cells of the ovary. Germ cell tumors begin in the reproductive cells (egg or sperm) of the body. Ovarian germ cell tumors usually occur in teenage girls or young women and most often affect just one ovary.. The ovaries are a pair of organs in the female reproductive system The median tumor diameter was 20 cm, four women had germ cell malignancies with diameters less than 15 cm, and twelve women (17%) had tumors with diameters greater than 30 cm. There was evidence of unilateral hydronephrosis on imaging studies in seven cases, and one had radiographic evidence of inferior vena cava compression
In the logistic regression model, no particular patients' characteristics—with the exception of mediastinal germ cell tumor localization and a nonseminomatous histology of endodermal sinus tumor (relative risk [RR] = 5.8; 95% CI = 1.6-21.2) or teratocarcinoma (RR = 13.5; 95% CI = 5.2-35.3)—could be identified that predicted the occurrence. A. Lindsay Frazier, James F. Amatruda, in Oncology of Infancy and Childhood, 2009. Dysgerminoma. Dysgerminoma is the most common malignant ovarian germ cell tumor of children and adolescents, and makes up one third of malignant ovarian GCTs. 243-245 Pathologically, dysgerminoma is the ovarian counterpart of the seminoma of the testis and the germinoma of extragonadal sites At present, PM in Germ Cell Tumors and Prostate Cancer must be discussed in a multidisciplinary tumor board to provide a maximally tailor-made approach with an integrated approach consisting of systemic therapy or less invasive technique, such as term ablation or stereotactic radiotherapy Germ cells form the eggs (ova) in females and the sperm in males. Germ cell tumors are made up of these underdeveloped cells. Germ cell tumors are rare. They may be cancer (malignant) or not cancer (benign). For more information regarding pediatric germ cell services in St. Louis, please call 314.454.5437 or 800.678.5437 or email us
KEYWORDS: germ cell tumor, benign teratoma, seminoma, nonseminomatous germ cell tumor, chemotherapy, peripheral blood stem cell transplantation. P rimary germ cell tumors (GCT) of the mediastinum are relatively rare and represent approximately 10-15% of mediastinal tumors. Malignant GCT in the mediastinum, which account for 1-4% o Intracranial malignant non-germinomatous germ cell tumors (NGGCTs) are a heterogeneous group of neoplasms mostly located in pineal and/or suprasellar regions. They include yolk sac tumor (YST), embryonal carcinoma (EC), choriocarcinoma (CHC), and mixed malignant tumors in various combinations, often together with teratoma or germinoma components Retroperitoneal germ cell tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration. World J Gastrointest Oncol. 2010 Dec 15. 2(12):443-5. . . Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y, et al. RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases Extragonadal Germ Cell Tumors is a fatal condition that can result in death, if early diagnosis and treatment is not provided. How is Extragonadal Germ Cell Tumor Treated? The treatment of the Extragonadal Germ cell Tumor is based on the stage, type, and location of the tumor. It may include: Surgical removal of the tumor (if it is benign teratoma Yolk sac tumor is a germ cell neoplasm that differentiates in the direction of the embryonic yolk sac, allantois, and extraembryonic mesenchyme. It is the most common testicular neoplasm in the pediatric population, accounting for approximately half of the prepubertal testis tumors. 19 , 114 , 115 Childhood yolk sac tumor does not appear to be.
Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad, which accounts for about 2.6% of all ovarian malignancies. There are four main types of OGCTs, namely dysgerminomas, yolk sac tumor, teratoma, and choriocarcinoma.. Dygerminomas are Malignant germ cell tumor of ovary and particularly prominent in patients diagnosed. The topic Germ Cell Tumor of Lung - Teratoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition Teratoma of Lung. Quick Summary: A Teratoma of Lung is the most common type of germ cell tumor of the lung
Introduction. Testicular germ cell tumors (GCTs) are the most common type of non-hematologic malignancy in males from the ages of 15 to 49. GCTs account for 1% of all male neoplasm ().Cryptorchidism, radiation, undescended testis, testicular dysgenesis (testicular feminization, Klinefelter syndrome) and family history are considered to be the main risk factors that could lead to developing GCT () Malignant ovarian germ cell tumor is a rare disease, but with current treatment strategies including surgery and platinum based chemotherapy survival is excellent. After treatment, intensive followup is indicated to encounter tumor relapse at an early stage. This case describes a 22-year-old female with a history of common variable immune deficiency (CVID) who underwent a resection of a large. Tumors arising from germ cells, which may differentiate along gonadal lines (seminoma), extra-embryonic lines (yolk sac tumor or choriocarcinoma) or transform to totipotential cells (undifferentiated: embryonal carcinoma or differentiated: teratoma).; Either pure (60%) or mixed (40%; >2 histology) tumors. Predisposing factors: cryptorchidism, testicular dysgenesis (e.g. testicular feminization. for multiple lung metastases of germ cell tumors. Arab J Intervent Radiol 2017;1:64-7. Introduction Wide surgical resection of residual lung masses is recommended for prognostic and therapeutic reasons after initial chemotherapy for metastatic germ cell tumors. First, only a complete resection of pulmonary metastases may be associate
If untreated, malignant extragonadal germ cell tumors may spread to the lungs, lymph nodes, bones, liver, or other parts of the body. Age and gender can affect the risk of extragonadal germ cell tumors. Risk factors for malignant extragonadal germ cell tumors include being male, being age 20 or older, and having Klinefelter syndrome Radiology description. Ultrasound: solitary hypoechoic lesion; not helpful in distinguishing from germ cell tumors Radiology images. Images hosted on other servers: Hypoechoic lesion. Prognostic factors. Vast majority are benign, ~ 5% cases are malignan Malignant germ cell tumors in the central nervous system are rare and not well known because they occur mainly in adolescents, an age in which patients are dispersed in adult and pediatric wards. Their biology starts to be unraveled by high-throughput genomics and their treatment is now well defined thanks to international studies, including. Germ cell tumors in the testes of an adolescent male commonly present as an enlarging, solid mass, which may be painful. Within the ovaries, germ cell tumors can usually be distinguished from ovarian cysts, which are much more common, using ultrasound. Germ cell tumors can spread to lymph nodes, lung, liver, and brain. Some germ cell tumors. The most frequent location of the germ cell tumors ap-peared to be the mediastinum (n=90), followed by the central nervous system (n=23), testis (n=15) and abdo-men (n=13) (Table 1). Especially in age 5-19years the mediastinal germ cell tumors comprise the largest frac-tion (Fig. 2). Children under the age of 5 show mor
Nonseminomatous germ cell tumors stages 1 & 2: treatment variable; some prefer lymph node dissection with further therapy dependent on presence / absence of tumor, some prefer watchful waiting unless aggressive features (vascular invasion, predominance of embryonal carcinoma) Most patients who die of tumor die within 2 years of diagnosi Metastatic germ cell tumor; By admin; 0 Comments; Management of Diagnosis and Treatment in a Case of Fibrolamellar Carcinoma. Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Department of Interventional Radiology, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy.
Discussion. Germ cell tumors are associated with a diverse histopathology and clinical prognosis. Approximately 20%-30% of patients with metastatic germ cell tumors have disease resistant to standard chemotherapy , and 15%-20% of these tumors are incurable with the available treatments .The optimal therapeutic approach for advanced germ cell tumors has not been established, and thus. Neoplasms exhibiting features of gonadal germ cell neoplasms arising in the mediastinum; Diagnostic Criteria. All types of gonadal germ cell tumors (GCT) may be seen in the mediastinum Mature teratoma is by far the most common type. Occurs roughly equally in males and females; Immature teratoma and all other types of GCT occur virtually only in. Testicular germ cell tumors account for approximately 1% of all newly diagnosed male cancers worldwide, and in 2012, there was estimated to be over 10,000 deaths from this disease . It is the most commonly diagnosed malignancy in men aged 15-40 in developed countries , an 5. • Germ cell tumors • Germ cell tumors arise from the ovary's germinal elements and comprise a third of all ovarian neoplasms. • The mature cystic teratoma, also called dermoid cyst, is by far the most common subtype. • This accounts for 95 percent of all germ cell tumors and is clinically benign. 6 Testicular ultrasonography (US) showed multiple, bilateral punctate echoes that are characteristic of TM. No primary testicular tumor was detected. Transthoracic needle biopsy of the mediastinal tumor was consistent with a mixed germ cell tumor. This is the seventh case of extragonadal germ cell tumor with TM
Germ cell brain tumors are tumors, usually cancerous, that arise in the pineal or suprasellar region of the brain. Different types of these germ cells cause different types of tumors, including the following: These tumors start and grow mainly in two areas in the center of the brain: However, a germ cell brain tumor can spread to other parts of. Germ cell tumors are cancerous (malignant) or noncancerous (benign) tumors made up mostly of germ cells. Germ cells are young cells that develop into eggs and sperm as they mature. Germ cell tumors are rare, accounting for about 1 percent of all childhood cancers.. Many germ cell tumors start in an ovary or testicle. However, some develop in the brain, chest, or abdomen and some start around.
Chromosome 12 abnormalities in malignant ovarian germ cell tumors. Rodriguez E, Melamed J, Reuter V, Chaganti RS: Cancer genetics and cytogenetics. 1995 ; 82 (1) : 62-66. PMID 7627937 : Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1 Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Testicular Germ Cell Tumors Germ cell tumors are associated with a diverse histopathol-ogy and clinical prognosis. Approximately 20%-30% of patients with metastatic germ cell tumors have disease resis-tant to standard chemotherapy , and 15%-20% of these tumors are incurable with the available treatments . Th Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. A germ cell is a type of cell that forms as a fetus (unborn baby) develops. These cells later become sperm in the testicles or eggs in the ovaries.. This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain) There are 2 types of staging for germ cell tumors, based on whether the patient has had surgery yet. First, the clinical stage is based on the results of tests done before surgery, such as a physical examination, CT scans, and MRI tests. Then, the pathologic stage is assigned based on information found during surgery, plus the laboratory.
Germ cell tumors make up about 20 to 25 percent of all abnormal tissue masses in the ovaries. Only five percent of ovarian cancers are germ cell tumors. The most common benign forms are benign teratomas or dermoids. Cancerous forms include dysgerminomas, yolk sac tumors, mixed germ cell tumors, and non-gestational choriocarcinomas Abstract. Background: Primary mediastinal malignant germ cell tumors (GCTs) are rare and have a worse prognosis than their gonadal counterparts. Although multimodality treatment is a standard therapeutic strategy in mediastinal GCTs, the clinical implications of surgical intervention remain unclear The metastatic tumor is the same type of tumor as the primary tumor. For example, if an extragonadal germ cell tumor spreads to the lung, the tumor cells in the lung are actually cancerous germ cells. The disease is metastatic extragonadal germ cell tumor, not lung cancer. The following prognostic groups are used for extragonadal germ cell tumors The stats • Germ cell tumors - Second most common group of ovarian tumors - All ages from infancy to old age - Seen most frequently from the first to the sixth decades (even during fetal life). - In children and adolescents, more than 60% of ovarian neoplasms are of germ cell origin, and one third are malignant Crafted as a descriptive and visual text, Germ Cell Tumors features definitive reviews of the biology, diagnosis, and management of germ cell tumors. Incorporating extensive illustrations and tables, this book reviews the progress that has been made in the curative therapy of germ cell tumors over the past 25 years, progress that has lead to the positioning of germ cell tumor therapy as the.
Intracranial germ-cell tumor (IC-GCT) is one of the most common pediatric brain tumors in Asia, comprising approximately 15% of pediatric brain tumors in Japan. 1. Treatment of IC-GCT has been continuously developing around the world over recent decades Testicular germ cell tumors arise in the absence of sex-specific differentiation In collection: Reproductive biology Nicholas J. Webster. 0000-0002-6016-7705 , Nicholas J. Webster 1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030,. Mixed Germ Cell Tumor of the Testis is a type of testicular cancer affecting the germ cells. Germ cells are precursors to sperm cells that will eventually transform into sperms. The testes are the male reproductive organs, equivalent to the ovaries in women. They are housed in the scrotum; the sac-like structure in the groin Mixed Germ Cell Tumor Regressed Germ Cell Tumors Germ cell tumors that have undergone either partial or complete regression (burnt-out), leaving behind a well-delineated nodular focus of scaring fibrosis in the testis. Can present with metastatic disease, but primary has completely regressed. Can be seminoma or Non-seminoma